Correlative study between MRI features of cavernous sinus invasion and expression of extracellular matrix metalloproteinase inducer and Galectin-3 in pituitary adenomas
ZHANG Yi-nian, HE Ning, ZHOU Jun-lin
Department of Radiology, the Second Hospital of Lanzhou University, Lanzhou 730030, China
Abstract：Objective: To investigate the correlation between MRI features of cavernous sinus invasion and expression of extracellular matrix metalloproteinase inducer(EMMPRIN) and Galectin-3 in pituitary adenomas. Methods: MRI was performed preoperatively in 34 patients with histologically verified pituitary adenomas, EMMPRIN and Galectin-3 expression were determined by immunohistochemical SP method in all patients. The correlation between expression of determined proteins and MRI features between invasive and non-invasive pituitary adenomas were studied. Results: Among MRI invasive features, Knosp score, Cottier score, irregular tumor shape and bilateral intracavernous carotid artery asymmetry correlated with increased expression of EMMPRIN and Galectin-3(P<0.05). Conclusion: MRI features of cavernous sinus invasion may be related to the expression of EMMPRIN and Galectin-3, MRI is very useful in diagnosing invasive extent of cavernous sinus in pituitary adenomas.
张祎年;何 宁;周俊林. 垂体腺瘤海绵窦侵袭的MRI表现与EMMPRIN和Galectin-3表达的相关性研究[J]. , 2008, 19(1): 10-14.
ZHANG Yi-nian;HE Ning;ZHOU Jun-lin. Correlative study between MRI features of cavernous sinus invasion and expression of extracellular matrix metalloproteinase inducer and Galectin-3 in pituitary adenomas. , 2008, 19(1): 10-14.
2008, Vol. 19 
