Evaluation the effect of simvastatin on vascular endothelial function by high frequency sonography in atherosclerotic rabbits
YANG Xin1, WANG Wei1, CAO Xia1, ZHENG Chun-mei1, MA Chun-yan2, REN Wei-dong2
1. Department of Physical Diagnosis, First Affiliated Hospital of Jiamusi University, Jiamusi Heilongjiang 154002, China;2. Department of Heart Function, First Affiliated Hospital of China Medical University, Shenyang 110001, China
Abstract:Objective: To assess the effect of simvastatin on vascular endothelial function by high frequency sonography. Methods: Fifty rabbits were randomly divided into control group(A group) and atherosclerotic group(B group) and simvastatin group(C group). Endothelial dependent dilation(EDD) and non-endothelial dependent dilation(NEDD) were measured with high resolution sonography at different time. Results: After intervention of simvastatin, the blood lipid decreased, EDD function was obviously improved, and NEDD was improved after 12 weeks. There was significant difference between the two groups. Conclusions: Simvastatin can improve endothelial function. High frequency sonography can be used to assess the effect of drug therapy on endothelial function.
杨 欣;王 薇;曹 霞;郑春梅;马春燕;任卫东. 应用高频超声评价辛伐他汀对动脉粥样硬化血管内皮功能的影响[J]. , 2010, 21(8): 547-548.
YANG Xin;WANG Wei;CAO Xia;ZHENG Chun-mei;MA Chun-yan;REN Wei-dong. Evaluation the effect of simvastatin on vascular endothelial function by high frequency sonography in atherosclerotic rabbits. , 2010, 21(8): 547-548.