The research of dual source CT perfusion parameter in biological behavior of gastric carcinoma
LI Chun-zhi1, XU Rong-tian2, YU Xiao-jing1, ZHANG Yuan-yuan1, JIN Yan1
1. Department of Radiology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China;2. Department of Radiology, First Hospital of China Medical University, Shenyang 110001, China
Abstract：Objective: To investigate the value of dual source CT perfusion imaging parameters, including blood volume(BV), blood flow(BF), and Patlak P value in evaluating the biological behavior of gastric carcinoma. Methods: Dual source CT perfusion imaging was performed in 98 patients of gastric carcinoma. The BV, BF, Patlak P value were obtained to study the relationship between the parameters of perfusion and the biological behavior in gastric cancer, and estimate the value of parameters. Results: The BF could predict gastric carcinoma had no distant metastasis with a sensitivity of 72.13%, a specificity of 64.52%, a positive predictive value of 81.67%, a negative predictive value of 52.63%, and an accuracy of 70.41%. The BV could predict the gastric carcinoma had no distant metastasis with a sensitivity of 68.66%, a specificity of 51.61%, a positive predictive value of 75.41%, a negative predictive value of 43.24%, and an accuracy of 63.27%. The BV could predict gastric carcinoma confined within the serous membrane with a sensitivity of 60.00%, a specificity of 69.57%, a positive predictive value of 86.54%, a negative predictive value of 34.78%, and an accuracy of 62.24%. Patlak P value could predict the gastric carcinoma confined within the muscularis with a sensitivity of 61.54%, a specificity of 75.86%, a positive predictive value of 69.57%, a negative predictive value of 68.75%, and an accuracy of 69.09%. Patlak P value also could predict the gastric carcinoma had protrude beyond the serous membrane with a sensitivity of 14.29%, a specificity of 69.23%, a positive predictive value of 60%, a negative predictive value of 20%, and an accuracy of 27.27%. Conclusion: The dual source CT perfusion imaging parameters could assess the biological behavior of gastric carcinoma, but there still has limitations.
2011, Vol. 22 
