Abstract：Objective: To explore the effect of hypoxia on carotid compliance and related cytokines in anti-seismic soldiers acute exposed to high altitude by using wave intensity(WI) technology and detection of changes of hypoxia induced factor(HIF-1α) and vascular endothelial growth factor(VEGF). Methods: One hundred anti-seismic soldiers acutely exposed to plateau within seven days at Yushu(the high altitude group) and one hundred healthy soldiers living on the plains(the control group) were enrolled, pressure-strain elastic modulus(Ep), stiffness parameter(β), arterial compliance(AC), argumentation index(AI) and pulse wave velocity(PWV-WI) were detected using WI technology, meanwhile VEGF and HIF-1α were measured. Results: Compared with the control group, HIF-1α, VEGF and PWV-WI were higher in the high altitude group(P<0.05). The Ep, β, AC, AI had no significant different between the two groups(P>0.05). Conclusions: In a hypoxia environment, increased HIF-1α and VEGF may had a regulating effect on carotid compliance. Carotid artery elasticity-pulse wave velocity is a sensitive variable reflecting acute high altitude hypoxia reaction.
刘爱玲;姚胜银;沈丽群;曹小勇;周爱香;阴海霞;姜海艳;马丽晶;杨巧玲. 急进高海拔地区的抗震官兵颈动脉弹性功能及相关细胞因子的变化初探[J]. , 2012, 23(4): 236-238.
LIU Ai-ling;YAO Sheng-yin;SHEN Li-qun;CAO Xiao-yong;ZHOU Ai-xiang;YIN Hai-xia;JIANG Hai-yan;MA Li-jing;YANG Qiao-ling. Study on changes of carotid compliance and related cytokines in anti-seismic soldiers on acute exposure to high altitude. , 2012, 23(4): 236-238.
2012, Vol. 23 
