The application of 11C-MET PET-CT in diagnosing the recurrence of cerebral glioma and in the target volume planning of three-dimensional conformal radiotherapy
YU Lei, WANG Ying-ying, CHE Xian-feng, SUN Ai-jun, SUN Xiao-gang
Wanjie Tumor Hospital of Zibo City, Zibo Shandong 255213, China
Abstract：Objective: To study the clinical value of 11C-MET PET-CT in the diagnosis of recurrent glioma and in planning radiation therapy target. Method: 11C-MET PET-CT examination was used in 22 glioma patients with cranial MRI enhanced scan diagnosed recurrence, pathological diagnosis obtained by craniotomy and biopsy, the three-dimensional conformal radiotherapy target was sketched using the combination of PET-CT images and MR images in 12 cases with pathologically confirmed recurrence. Results: PET-CT imaging of 22 patients with 11C-MET: true positive 16 cases, true negative 5 cases, false positive 1 case and no false negative cases, the sensitivity was 95.5%(21/22), the specificity was 83.3%(5/6), the false-positive rate was 16.7%(1/6), the false-negative rate was 0, Youden index 0.788; 12 patients with histologically confirmed recurrence were given the three-dimensional conformal radiotherapy, target range of 4 cases was consistent with T1WI enhanced region, 2 cases was greater than T1WI enhanced region, four cases was less than T1WI enhanced region, the target range of 2 cases located entirely outside T1WI enhanced region. Conclusion: 11C-MET PET-CT has a high accuracy in the diagnosis of glioma recurrence, can be used in cases of MRI/CT diagnosis of recurrent, but the clinical diagnosis is not yet confirmed, and can obviously optimize radiotherapy planning in patients with glioma recurrence.
于 雷;王莹莹;车现锋;孙爱君;孙效刚. 11C-蛋氨酸PET-CT在诊断脑胶质瘤复发和三维适形放疗靶区规划中的临床应用[J]. , 2013, 24(6): 385-388.
YU Lei;WANG Ying-ying;CHE Xian-feng;SUN Ai-jun;SUN Xiao-gang. The application of 11C-MET PET-CT in diagnosing the recurrence of cerebral glioma and in the target volume planning of three-dimensional conformal radiotherapy . , 2013, 24(6): 385-388.
2013, Vol. 24 
