MR perfusion weighted imaging combined with MR diffusion weighted imaging in differentiating recurrent cerebral gliomas and radiation injury
SHA Lin1, FAN Guo-guang2, CAO Qian1, BIAN Jie1
1. Department of Radiology, the Second Affiliated Hospital of Dalian Medical University, Dalian Liaoning 116027, China;2. Department of Radiology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China
Abstract：Objective: To evaluate the value of MR perfusion weighted imaging(PWI) combined with MR diffusion weighted imaging(DWI) in the diagnosis of cerebral glioma recurrence and radiation injuries. Methods: Fifty-two patients who had cerebral gliomas were treated with radiotherapy after operation. They underwent routine MR, PWI and DWI due to the discovery of new lesions after radiotherapy. The value of rCBVmax and ADCmin in the new lesion were measured. According to pathology and clinical follow up, the value of combined PWI and DWI in differentiating tumor recurrence and radiation injury were analyzed. Results: In the 52 cases, recurrence of cerebral glioma were 30 cases, radiation injury 22 cases. The rCBVmax value in the recurrent lesion was 2.43±1.52, the value of ADCmin was 0.86±0.21, while the rCBVmax in the radiation injured lesion was 0.67±0.44, and the ADCmin value was 1.17±0.27, there were statistical differences, P=0.000. The accuracy rate of DWI and PWI were 76.9% and 82.7% respectively, the accuracy rate of combined PWI and DWI was 90.4%. Conclusion: MR PWI and DWI are valuable in differentiating recurrent cerebral glioma and radiation injury, combined the two sequences can raise up the accuracy rate of diagnosis.
2013, Vol. 24 
