摘要目的：分析和探讨产前超声诊断的孤立性透明隔腔消失（Absence of septum pellucidum，ASP）胎儿的临床特点及预后情况。方法：对2009年1月—2012年12月于我院行超声检查并诊断为胎儿孤立性ASP的病例进行回顾性分析，并进行产后的追踪随访，重点观察其神经系统的发育情况。结果：产前超声诊断并活产，产后资料完整的孤立性ASP胎儿共14例，其中2例发生神经系统发育迟滞（1例语言及行为障碍，1例为视-隔发育不良及语言障碍），余12例未见异常。5例胎儿于产前行MRI检查，其中4例提示视束及视交叉正常，1例难以评估。结论：超声检查是产前发现胎儿孤立性ASP的有效方法，MRI可作为重要的验证和补充的诊断手段；孤立性ASP胎儿总体预后较好，但应重视出生后的随诊观察，尤其是神经、精神、心理发育的远期评估。
Abstract：Objective: To evaluate the clinical characteristics and the corresponding outcome of fetuses with isolated absence of septum pellucidum(ASP) diagnosed by prenatal ultrasonography. Methods: Clinical data of 14 fetuses with isolated ASP diagnosed in our hospital were from January 2009 to December 2012 analyzed retrospectively. Postnatal follow-up was also conducted, and children’s nervous system development was emphatically observed. Results: Totally 14 ASP fetuses were born and successfully followed up, 12 had normal neurological examinations, 2 got nervous system developmental retardation(one had language deficit and behavioral problem, the other one diagnosed as septo-optic dysplasia and language development delay). Five fetuses underwent MRI examination, of which 4 had normal optic chiasma and optic track, one was difficult to assess. Conclusion: Ultrasonography is an effective method for prenatal identification of ASP. MRI serves to confirm the sonographic findings as well as offering additional diagnostic information. These lesions, when isolated, may be associated with a favorable outcome, however, postnatal follow-up should be strongly emphasized, especially the assessment of neuropsychological and psychiatric development of children with isolated ASP.
2013, Vol. 24 
