与人脑白质磁共振弛豫时间近似的琼脂凝胶模型制备的实验研究

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (0 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的：建立最接近正常成人脑白质弛豫时间的琼脂及钆对比剂浓度配比的磁共振实验模型。方法：将浓度为0.03 mmol/L、0.06 mmol/L、0.09 mmol/L、0.2 mmol/L、0.4 mmol/L、0.6 mmol/L及0.8 mmol/L的钆特酸葡胺分别与1.0%、1.5%（g/dl）的琼脂混合制成模型。将模型固定于成人志愿者头颅周围行MRI扫描得到T1、T2 map图。测定各种浓度配比模型的弛豫时间，分别得到T1、T2值的回归方程。通过单变量求解计算出接近人脑白质弛豫时间95%可信区间（均值）的浓度配比。并根据计算得到的浓度配比配制成模型后与志愿者脑白质弛豫时间作进一步对比验证。结果：人脑白质T1、T2值95%可信区间（均值）分别为792.14~848.59（820.36） ms、83.45~86.09（84.77） ms。0.10~0.11 mmol/L（0.11 mmol/L）钆特酸葡胺与1%琼脂混合、0.09~0.10 mmol/L（0.10 mmol/L）钆特酸葡胺与1.5%琼脂混合后的弛豫时间与脑白质T1值95%可信区间上限值与下限值（均值）接近；0.49~0.56 mmol/L（0.52 mmol/L）钆特酸葡胺与1%琼脂混合、0.08~0.12 mmol/L（0.10 mmol/L）钆特酸葡胺与1.5%琼脂混合的弛豫时间与脑白质T2值95%可信区间上限值与下限值（均值）近似。结论：1.5%的琼脂与0.09~0.10 mmol/L的钆特酸葡胺配比制成的模型T1、T2值均接近正常成人脑白质，能用于模拟正常成人的脑白质MRI信号。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	葛祖峰1
	龚向阳2
	朱莉莉1
	朱时锵1
	吴伟1
	单登峰1

关键词 ：脑, 凝胶类, 磁共振成像

Abstract：Objective: To set up an MR study model for an appropriate mix ratio of agar and gadoteric acid similar to the relaxation time of white matter of adult brain. The mixture is expected to be a substitution of adult brain in MRI experiment. Methods: After a phantom was made of 0.03 mmol/L, 0.06 mmol/L, 0.09 mmol/L, 0.2 mmol/L, 0.4 mmol/L, 0.6 mmol/L, 0.8 mmol/L gadoteric acid mixed with 1%(g/dl) and 1.5%(g/dl) agar respectively, it was fixed around adult brains(n=11) to be scanned by a 1.5T superconducting unit to get T1 and T2 maps. Then the curve equations were fitted by regression analysis of T1, T2 values of every mixture. Single goal seeking was used to calculate the ranges of mix ratio matching to the relaxation times of 95% CI(means) of brain white matter. According to the calculated mix ratio, another phantom was made to compare it’s relaxation times to the white matter. Results: The 95% CIs(means) of T1 and T2 of white matter were 792.14~848.59(820.36) ms and 83.45~86.09(84.77) ms, respectively. The calculated mix ratio matching to the 95% CI(means) of T1 of white matter as follow: 0.10~0.11 mmol/L(0.11 mmol/L) gadoteric acid mixed with 1% agar, 0.09~0.10 mmol/L(0.10 mmol/L) gadoteric acid mixed with 1.5% agar. The calculated mix ratio matching to the 95% CI(means) of T2 of white matter as follow: 0.49~0.56 mmol/L(0.52 mmol/L) gadoteric acid mixed with 1% agar, 0.08~0.12 mmol/L(0.10 mmol/L) gadoteric acid mixed with 1.5% agar. Conclusion: A range of 0.09~0.10 mmol/L gadoteric acid mixed with 1.5% agar is an appropriate mix ratio matching to the both T1 and T2 value of adult brain white matter, which can provide an analog MRI signal of human white matter.

Key words： Brain Gels Magnetic resonance imaging

PACS:	Ｒ338.2
	Ｒ445.2

通讯作者: 龚向阳

引用本文:

葛祖峰1，龚向阳2，朱莉莉1，朱时锵1，吴伟1，单登峰1. 与人脑白质磁共振弛豫时间近似的琼脂凝胶模型制备的实验研究[J]. 中国临床医学影像杂志, 2016, 27(3): 157-160.
GE Zu-feng1, GONG Xiang-yang2, ZHU Li-li1, ZHU Shi-qiang1, WU Wei1, SHAN Deng-feng1. A model for an appropriate mix ratio of agar and gadoteric acid similar to the relaxation time of#br# white matter of human brain: experiment study. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(3): 157-160.

链接本文:

http://www.jccmi.com.cn/CN/ 或 http://www.jccmi.com.cn/CN/Y2016/V27/I3/157

[1]Hu XY, Ge ZF, Zee CS, et al. Differentiation of white and red thrombus with magnetic resonance imaging: a phantom study[J]. Chin Med J(Engl), 2012, 125(11): 1889-1892.
[2]Bazrafshan B, Hübner F, Farshid P, et al. A liver-mimicking MRI phantom for thermal ablation experiments[J]. Med Phys, 2011, 38(5): 2674-2684.
[3]龚向阳，李森华，李蓉芬，等. 磁共振信号演变规律的实验研究[J]. 中华放射学杂志，1999，23（10）：708-712.
[4]倪红艳，祁吉，张文波，等. 磁化传递技术在提高膝关节磁共振影像对比中的应用[J]. 临床放射学杂志，1999，18（9）：561-564.
[5]柳盈盈，卢晓静，郑卓肇，等. 借助磁共振成像可定位的Eudragit-E液体栓塞剂的制备及性质[J]. 北京大学学报：医学版，2014，46（5）：744-750.
[6]Akter M, Hirai T, Hiai Y, et al. Detection of hemorrhagic hypointense foci in the brain on susceptibility-weighted imaging clinical and phantom studies[J]. Acad Radiol, 2007, 14(9): 1011-1019.
[7]Eibofner F, Steidle G, Kehlbach R, et al. Positive contrast imaging of iron oxide nanoparticles with susceptibility-weighted imaging[J]. Magn Reson Med, 2010, 64(4): 1027-1038.
[8]尤剑颖，史凯宁，包尚联. 测量T1值确定最佳翻转角的三激发角方法[J]. 中国医学影像技术，2011，27（9）：1899-1902.
[9]van Schie JJ, Lavini C, van Vliet LJ, et al. Feasibility of a fast method for B1-inhomogeneity correction for FSPGR sequences[J]. Magn Reson Imaging, 2015, 33(3): 312-318.
[10]Cheng HL, Wright GA. Rapid high-resolution T(1) mapping by variable flip angles: accurate and precise measurements in the presence of radiofrequency field inhomogeneity[J]. Magn Reson Med, 2006, 55(3): 566-574.
[11]康宁，俎栋林，张宏杰. 自旋密度ρ、弛豫时间T1和T2定量磁共振成像[J]. 中国医学影像技术，2004，20（12）：1944-1947.
[12]Duncan JS, Bartlett P. Technique for measuring hippocampal T2 relaxation time[J]. AJNR, 1996, 17(10): 1805-1810.
[13]Deoni SC, Rutt BK, Peters TM. Rapid combined T1 and T2 mapping using gradient recalled acquisition in the steady state[J]. Magn Reson Med, 2003, 49(3): 515-526.
[14]Watrin A, Ruaud JP, Olivier PT, et al. T2 mapping of rat patellar cartilage[J]. Radiology, 2001, 219(2): 395-402.
[15]Baselice F, Ferraioli G, Grassia A, et al. Optimal configuration for relaxation times estimation in complex spin echo imaging[J]. Sensors(Basel), 2014, 14(2): 2182-2198.