Abstract：Objective: To investigate the dynamic performance of neuromyelitis optica(NMO) in serial magnetic resonance imaging(MRI) examinations. Materials and Methods: Five female patients with NMO(26.6±13.1 years old(range, 16~49 years old) were enrolled, their serial MRI data during the therapeutic and follow-up period were reviewed retrospectively. Result: All of the five patients with NMO had experienced visual impairment for one or more times, and segmental or diffused spinal cord lesion with edema(mainly affecting central gray matter) and slightly contrast-enhancement was demonstrated in their first MRI examination. In the first MRI examination, 2 patients with NMO also presented with optic chiasm swelling, thickening and mild contrast enhancement, with hypothalamus partly involved in one of them; one of these 5 patients presented with scattered small lesions in the brain. During the therapeutic and follow-up period, MRI demonstrated dynamic changes of spinal cord edema according to the illness conditions, probably with a migration of lesion location. Conclusion: NMO is a kind of recurrent, demyelinating disease mostly affecting optic nerve and spinal cord, MRI can provide reasonable basis for the clinical treatment by monitoring the dynamic changes of NMO lesions.
[1]Lennon VA, Wingerchuk DM, Kryzer TJ, et al. A serum autoantibody marker of neuromyelitis optics: distinction from multiple sclerosis[J]. Lancet, 2004, 364(9451): 2016-2112.
[2]Wingerchuk DM, Lennon VA, Lucchinetti CF, et al. The spectrum of neuromyelitis opica[J]. Lancet Neurol, 2007, 6(9): 805-815.
[3]Wingerchuk DM, Lennon VA, Pittock SJ, et al. Revised diagnostic criteria for neuromyelitis optica[J]. Neurology, 2006, 66(10): 1485-1489.
[4]Kazuka T, Usui Y, Yamakawa N, et al. Relationship between NMO-antibody and anti-MOG antibody in optic neuritis[J]. Neuro-ophthalmol, 2012, 32(2): 107-110.
[5]梅文杰，王文敏. 视神经脊髓炎的相关研究进展[J]. 实用临床医学，2014，15（11）：136-139.
[6]Takahashi T, Miyazawa I, Misu T, et al. Intractable hiccup and nausea in neuromyelitis optica with anti-aquaporin-4 antibody: a herald of acute exacerbations[J]. Neurosurg Psychiatry, 2008, 79(9): 1075-1078.
[7]祁文军，张义，罗亨勤. 多发性硬化与视神经脊髓炎的共性与特性[J]. 西南国防医药，2014，24（12）：1389-1400.
2016, Vol. 27 
