Abstract：Objective: To explore the application value of 18F-FDG PET/CT in delineation of radiotherapy target area and clinical stage in non-small cell lung cancer, and to provide a basis for formulation of treatment plan. Methods: Eighty patients confirmed with non-small cell lung cancer by cytology or pathology and suitable for radiotherapy from January 2014 to November 2015 in our hospital were enrolled in this study. In which, 51 cases were squamous cell carcinoma, 29 cases were adenocarcinoma. Breast enhancement CT and 18F-FDG PET/CT were performed in all patients, and GTVPET/CT and GTVCT were determined, and the difference was compared statistically. Results: ①GTVPET/CT((20.74±15.57) cm3) was 24.16% smaller than GTVCT((26.33±17.31) cm3), and the difference was statistically significant(P<0.05). ②GTVCT and GTVPET/CT were (27.85±15.79) cm3 and (22.35±14.06) cm3 respectively in squamous carcinoma group, GTVCT and GTVPET/CT were (25.46±18.21) cm3 and (19.83±16.44) cm3 respectively in adenocarcinoma group, and GTVCT were bigger than GTVPET/CT in both groups, and the difference was significant statistically(P<0.05). ③18F-FDG PET/CT changed the clinical stage in 46 patients(57%) in all patients, in which 35 cases were up regulated, 11 cases were down regulated. Conclusion: 18F-FDG PET/CT can be helping in distinguishing tumor tissue with the surrounding atelectasis or inflammation, and in delineation of radiotherapy target area, and also in accurate clinical staging.
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