Preliminary study of shear wave elastography in the application in diagnosis and grading of nonalcoholic fatty liver disease
HE Peng, REN Bo, LI Ling, TANG Ying, ZHENG Xiao-yan, GU Peng
Sichuan Key Laboratory of Medical Imaging, Department of Ultrasound, Affiliated Hospital of North Sichuan
Medical College, Nanchong Sichuan 637000, China
Abstract：Objective: To explore the application value of shear wave elastography(SWE) in diagnosis of nonalcoholic fatty liver disease(NAFLD), by detection and analysis the liver stiffness measurement(LSM) of rabbits with NAFLD by SWE, in order to provide a practical and noninvasive clinical diagnosis technology of NAFLD. Methods: The 45 New Zealand white rabbits were divided randomly into the experimental group(n=35, with high fat diet) and the control group(n=10, with normal diet). The total test time was 24 weeks. We tested the LSM of all the rabbits in time of 16th and 24th week then killed all the rabbits and observed the liver histopathology after the ultrasonic test at the time of 24th weekend. Independent samples T-test of the various indexs of the rabbits in the two groups was performed using SPSS statistical software, version 22(SPSS Inc., Chicago, IL, USA) with all the data displayed as means±standard deviation. Pearson’s correlation coefficient was used for analysis the LSM with the liver fibrosis(LF), and the receiver operating characteristic curve(ROC) was constructed to analyze the detection efficiency of LSM in the diagnosis of LF. Results: All the 28 high fat diet rabbits survived were involved in the experiment group, and the 10 rabbits in normal control group were all survived. LSM in experimental group were higher than the control group in time of 16th and 24th week respectively(P all<0.05). And the LSM in the experimental group in time of 24th week was higher than the LSM in time of 16th week(t=10.857, P<0.05). The pathological in the experiment group results show that there were 5 rabbits at stage S0, 7 rabbits at stage S1, 11 rabbits at stage S2, 3 rabbits at stage S3, 2 rabbits at stage S4. The difference of LSM between different level of LF had statistical significance(F=390.381, P<0.001), the degree of LF and LSM showed a linear correlation(r=0.940, P=0.000). The areas under the ROC curve(AUC) was 0.918 when LSM diagnosis LF>S0, AUC was 0.933 when LF>S1, AUC was 0.966 when LF>S2, AUC was 0.974 when LF>S3 (early cirrhosis). Conclusion: SWE has high accuracy in the diagnosis and grading of NAFLD in rabbits, and may have a good application value in the evaluation of patients with NAFLD.
贺 鹏，任 波，李 玲，唐 盈，郑小艳，顾 鹏. 剪切波弹性成像技术在非酒精性脂肪性肝病诊断及肝纤维化分级中应用的初步研究[J]. 中国临床医学影像杂志, 2017, 28(9): 637-641.
HE Peng, REN Bo, LI Ling, TANG Ying, ZHENG Xiao-yan, GU Peng. Preliminary study of shear wave elastography in the application in diagnosis and grading of nonalcoholic fatty liver disease. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(9): 637-641.
2017, Vol. 28 
