分子功能影像在头颈部副神经节瘤的临床应用

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摘要头颈部副神经节瘤生长缓慢，多为良性肿瘤，也可能发生转移。头颈部副神经节瘤通常无儿茶酚胺分泌功能，几乎均为琥珀酸脱氢酶基因种系突变，过表达生长抑素受体。常规解剖成像诊断的灵敏度和特异性较低。随着分子功能成像的发展，利用分子功能影像进行肿瘤显像逐渐在临床中得到应用，可以明显提高头颈部副神经节瘤诊断的灵敏度和特异性。分子功能影像不仅对头颈部副神经节瘤的检出率较高，还可以明显提高全身其他部位的副神经节瘤和转移灶的检出，显著影响患者的治疗方案。

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	胡月
	马秀岚

关键词 ：头颈部肿瘤, 副神经节瘤, 正电子发射断层显像术, 体层摄影术, X线计算机

Abstract：Paragangliomas of head and neck are usually slow-growing tumors that are benign in most cases. Metastasis may also occur. Paragangliomas in head and neck usually do not produce catecholamines and related substances. They almost all have succinate dehydrogenase gene germline mutations and overexpression of somatostatin receptor. Conventional anatomical imaging has low sensitivity and specificity for detecting head and neck paragangliomas. Molecular imaging is gradually used in clinical diagnosis, which can significantly improve the sensitivity and specificity of the diagnosis of head and neck paragangliomas. Molecular imaging is useful for detection and characterization of head and neck paragangliomas and to demonstrate synchronous paragangliomas at other sites and distant metastases, which is critical because it can significantly affect treatment plan of patients.

Key words： Head and neck neoplasms Paraganglioma Positron-emission tomography Tomography, X-ray computed

收稿日期: 2017-07-19

PACS:	Ｒ739.91
	Ｒ730.264
	Ｒ817.4
	Ｒ814.42

通讯作者: 马秀岚，中国医科大学附属盛京医院耳科，110004。E-mail：maxl1@sj-hospital.org

作者简介: 胡月（1990-），男，辽宁沈阳人，助教。E-mail：1010698671@163.com

引用本文:

胡月，马秀岚. 分子功能影像在头颈部副神经节瘤的临床应用[J]. 中国临床医学影像杂志, 2018, 29(6): 439-442.
HU Yue, MA Xiu-lan. Application of molecular imaging in paraganglioma of head and neck. JOURNAL OF CHINA MEDICAL IMAGING, 2018, 29(6): 439-442.

链接本文:

http://www.jccmi.com.cn/CN/ 或 http://www.jccmi.com.cn/CN/Y2018/V29/I6/439

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