Abstract：Objective: To explore the efficacy and clinical value of multi-mode 3.0T MRI in the differential diagnosis of benign and malignant breast non-mass-like enhancement(NMLE) lesions. Methods: The data of 90 cases of breast NMLE lesions confirmed by operation and pathology and examined by 3.0T MRI were analyzed retrospectively. Among them, 31 cases were benign lesions(benign group) and 59 cases were malignant lesions(malignant group), all of them were female. Average age was 46.3±9.1. The distribution types, enhancement characteristics and time-intensity curve(TIC) on DCE-MRI were analyzed and compared between the two groups. The optimal threshold, diagnostic sensitivity and specificity of ADC were detected and determined on DWI. Results: ①Distribution type: dutcal type, segmental type, regional type and diffusive type, among which, the difference of segmental type distribution between the two groups was statistically significant(P<0.05), while the difference of the rest was not statistically significant(P>0.05);②Characteristic of enhanced lesions: the homogeneous, the heterogeneous, the clumped and the clustered ring. The clumped enhancement in the two groups had statistical significance(P<0.05), and the remaining variances were not statistically significant(P>0.05); ③The types of TIC in the two groups were not statistically significant(P>0.05); ④ADC value: The average ADC values of the two groups were (1.11±0.32)×10-3 mm2/s, (1.47±0.37)×10-3 mm2/s, and the difference was statistically significant(P<0.05), When the ADC value was less than or equal to 1.3×10-3 mm2/s, the sensitivity and specificity of diagnosing NMLE lesions as malignant lesions was 71.8% and 78.8% respectively. Conclusion: The application of DCE-MRI and ADC value measurement provides morphological and functional information that is helpful to distinguish benign and malignant breast NMLE lesions.
刘 靓，朱 丹，沈 晶，伍建林. 多模态MRI技术在乳腺非肿块性强化病变良恶性鉴别中的临床研究[J]. 中国临床医学影像杂志, 2020, 31(1): 15-19.
LIU Liang, ZHU Dan, SHEN Jing, WU Jian-lin. Clinical study of multi-mode MRI in differentiating benign and malignant breast non-mass-like enhancement lesions. JOURNAL OF CHINA MEDICAL IMAGING, 2020, 31(1): 15-19.
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