Correlation study of experimental superparamagnetic iron oxide-enhancedmagnetic resonance imaging of splenic VX2 tumor in rats with pathology
YANG Hong-yan1, XU Yi-kai2, WU Yuan-kui2, LIU Wen-yuan3, LV Guo-shi2, CAO Guo-hong2
1.Department of Medical Imaging, Chengdu Army General Hospital, Chengdu 610083, China;2.Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;3.Department of Medical Imaging, Shenyang Army General Hospital, Shenyang 110016, China
Abstract：Objective: To establish a rodent model of VX2 tumor in spleen of rats. To analyze relationship between the change of the signal intensity on superparamagnetic iron oxide(SPIO) enhanced MR images and pathologic change. To discuss the value of SPIO enhanced detection in splenic metastasis in rat. Methods: Eight rodent model of VX2 tumor in spleen was established successfully. The images were obtained before and after administration of superparamagnetic iron oxide. T1-weighted spin-echo(SE) pulse sequence with a repetition time (TR) of 450ms, and echo time(TE) of 12ms(TR/TE=450/12) were performed. The imaging parameters of T2-weighted SE pulse sequence as follows: TR/TE=4000/128. Results: On SPIO enhancement T2WI sequence the SI of splenic parachyma decreased obviously with percentage of signal intensity loss(PSIL) was 55.04%, but the SI of tumor was not evidently change with PSIL was 0.87%. Nevertheless the SNR of normal splenic parenchyma around the lesions had obvious difference(P<0.001) comparatively. The contrast-to-noise(CNR) between VX2 tumor and splenic parenchyma had an evidently difference with before and after admininstration of SPIO(P<0.001). Conclusions: On SPIO enhanced T2WI the contrast degree of lesions increased obviously. Consequently, SPIO-enhanced T2WI MRI scanning can improve the rate of detection and characterization in lesions of spleen.
阳红艳;许乙凯;吴元魁;刘文源;吕国士;曹国洪. 超顺磁性氧化铁粒子增强MR成像在脾脏荷VX2肿瘤动物模型的影像学与病理学对照研究[J]. , 2007, 18(10): 710-715.
YANG Hong-yan;XU Yi-kai;WU Yuan-kui;LIU Wen-yuan;LV Guo-shi;CAO Guo-hong. Correlation study of experimental superparamagnetic iron oxide-enhancedmagnetic resonance imaging of splenic VX2 tumor in rats with pathology. , 2007, 18(10): 710-715.
2007, Vol. 18 
