Abstract：Objective: To understand the rule of velocity of water molecules in normal vitreous body at different ages, so as to find vitreous body abnormalities early, and to take early treatment or intervention. Methods: From July 2016 to December 2017, a total of 162 normal persons(324 eyes) were retrospectively analyzed. MRI data was divided into 9 groups according to age: A group 0~<10 years old, B group 10~<20 years old, C group 20~<30 years old, D group 30~<40 years old, E group 40~<50 years old, F group 50~<60 years old, G group 60~<70 years old, H group 70~<80 years old, I group 80~<90 years old. MR diffusion weighted imaging(Propeller-DWI) of two eyeballs and vitreous body in each age group was performed, and the apparent diffusion coefficient(ADC) value of the region of interest was measured. Results: Variance analysis showed that the ADC value of the vitreous body increased first and then decreased with age, and then tended to be stable. There was a statistically significant difference between the two groups(P=0.00). Conclusion: The movement speed of normal vitreous body water molecules rises first and then decreases with the increase of age, and then tends to be stable.
王 巍，李如雪，张 念. 各年龄段正常玻璃体水分子运动速度的初步探讨[J]. 中国临床医学影像杂志, 2018, 29(12): 857-859.
WANG Wei, LI Ru-xue, ZHANG Nian. Movement speed of water molecules in normal vitreous body at different ages: a preliminary study. JOURNAL OF CHINA MEDICAL IMAGING, 2018, 29(12): 857-859.
[1]Bogner W, Pinker-Domenig K, Bickel H, et al． Readout-segmented echo-planar imaging improves the diagnostic performance of diffusion-weighted MR breast examinations at 3.0T[J]． Ｒａｄｉｏｌｏｇｙ, ２０１２, ２６３(１): ６４－７６．
[2]王树，阮海威，林鹤． ＤＷＩ在软组织肿瘤中的应用价值[J]． 中国中西医结合影像学杂志，２０１６，１４（６）：７２９－７３１．
[3]Xu XQ, Cheng QG, Zu QQ, et al． Comparative study of the relative signal intensity on DWI, FLAIR, and T2 images in identifying the onset time of stroke in an embolic canine model[J]． Ｎｅｕｒｏｌ Ｓｃｉ, ２０１４, ３５(７): １０５９－１０６５．
[4]张晓燕，李晓婷，史燕杰，等． 高分辨率ＭＲ Ｔ２ＷＩ联合ＤＷＩ评价直肠癌新辅助治疗后病理学完全缓解[J]． 中国介入影像与治疗学，２０１７，１４（３）：１６４－１６８．
[5]Morelli J, Porter D, Ai F, et al． Clinical evaluation of single-shot and readout-segmented diffusion-weighted imaging in stroke patients at 3T[J]． Acta Radiol, 2013, 54(3): 299-306.
[6]Byeon J, Kim JY, Cho AH. Readout-segmented echo-planar imaging in diffusion-weighted MR imaging of acute infarction of the brainstem and posterior fossa: comparison of single-shot echo-planar diffusion-weighted sequences[J]． Clin Imaging, 2015, 39(5): 765-769.
[7]Kim YJ, Kim SH, Kang BJ, et al． Readout-segmented echo-planar imaging in diffusion-weighted mr imaging in breast cancer: comparison with single-shot echo-planar imaging in image quality[J]． Korean J Radiol, 2014, 15(4): 403-410．
[8]杨正汉，冯逢，王霄英. 核磁共振成像技术指南[M]. 2版. 北京：人民军医出版社，2010：270-271.
[9]Sudhalkar AA, Praveen MR, Vasavada VA, et al． Subtle signs of an intact anterior vitreous face during pediatric cataract surgery[J]． J Cataract Refract Surg, 2012, 38(9): 1690-1693.
[10]Walia S, Clermont AC, Gao BB, et al． Vitreous proteomics and diabetic retinopathy[J]． Semin Ophthalmol, 2010, 25(5-6): 289-294．
[11]Sanches LR, Seulin SC, Leyton V, et al． Determination of opiates in whole blood and vitreous humor: a study of the matrix effect and an experimental design to optimize conditions for the enzymatic hydrolysis of glucuronides[J]． J Anal Toxicol, 2012, 36(3): 162-170.
[12]Le Goff MM, Bishop PN. Adult vitreous structure and postnatal changes[J]． Eye(Lond), 2008, 22(10): 1214-1222.
[13]Itakura H, Kishi S, Kotajima N, et al． Decreased vitreal hyaluronan levels with aging[J]． Ophthalmologica, 2009, 223(1): 32-35．
[14]Wang H, Feng L, Hu JW, et al． Characterisation of the vitreous proteome in proliferative diabetic retinopathy[J]． Proteome Sci, 2012, 10(1): 15.
