Abstract:Objective: To investigate the differences in airway quantitative parameters of respiratory biphasic CT and the correlation between various parameters and pulmonary function in patients with chronic obstructive pulmonary disease(COPD). Methods: We retrospectively analyzed 47 patients with pulmonary function diagnosed as COPD who underwent expiratory and inspiratory biphasic CT scan. Then we imported the data into the “Dexin-FACT” automatic analysis software, quantitatively analyzed the airway parameters in right lower lobe, including the mean wall thickness(MWT) of the bronchus, the average diameter(MLD) of the bronchial lumen, the mean wall area(MWA) of the bronchial wall area and the percentage of the wall area(mean wall ratio, WA%). Paired sample t test was used to determine the differences of CT parameters; correlation between MWT, MLD, MWA, WA% and lung function was performed by using Preason correlation analysis. Results: There were significant differences in bronchial MWT, MLD, MWA and WA% between the two groups of respiratory and inspiratory phases(P<0.05). MWT of inspiratory was bigger than expiratory; MLD and MWA of expiratory are bigger than inspiratory phase; there were statistically significant differences in WA% between biphasic CT in 0~3th generations of bronchi(P<0.05). WA% of inspiratory was bigger than expiratory, there were no statistically significant differences among WA% of 4th~9th generations bronchi(P>0.05). The MWT, MLD, MWA, WA% and FEV1%, FEV1/FVC, MEF25% of 9th generation bronchi in biphasic CT have correlations in the right lower lobe(P<0.05); In 8th generation of bronchi, MWT and FEV1% at expiratory, MWT and MEF25% in biphasic CT, MLD and MEF25% in biphasic CT, WA and FEV1%, MEF25% in biphasic CT, WA and FEV1/FVC at expiratory, WA% and FEV1%, FEV1/FVC, MEF25% in biphasic CT were have some correlations(P<0.05); There were some correlations between WA% and FEV1%, FEV1/FVC, MEF25% of 7th generation of bronchi in biphasic CT(P<0.05). The quantitative parameters of each bronchus have negative correlations with PFT, and the correlations increased with the increase of generations. The correlations between parameters at expiratory and PFT was higher than that of inspiratory. The WA% of bronchi of 9th generation in expiratory have the highest correlation with MEF25%(|r|=0.697, P<0.05). There were no correlations between other bronchi and PFT(P>0.05). Conclusion: Biphasic CT scanning is important for the diagnosis of small airway diseases in patients with COPD, so as to better guide clinical individualized treatment.
赵凡惠,王 雷,朱彦瑾,李建龙,郭佑民,黄晓旗. 基于呼、吸双相CT在慢性阻塞性肺疾病患者气道病变的定量分析[J]. 中国临床医学影像杂志, 2019, 30(12): 855-858.
ZHAO Fan-hui, WANG Lei, ZHU Yan-jin, LI Jian-long, GUO You-min, HUANG Xiao-qi. Quantitative analysis of airway disease in patients with chronic obstructive pulmonary disease based on biphasic CT. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(12): 855-858.
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