Abstract：Objective: To observe the characteristics of retrograde Wallerian degeneration of corticospinal tract(CST) in patients with cervical spondylotic myelopathy by diffusion tensor imaging(DTI), and to analyze the relationship between the degree of damage of corticospinal tract and limb motor dysfunction. Materials and Methods: A total of 28 CSM patients and 28 sex-, age- and education-matched healthy controls underwent conventional MRI and DTI examinations. The fractional anisotropy(FA) values and apparent diffusion coefficient(ADC) values of ROI in the bilateral pons, cerebral peduncle, posterior limb of internal capsule, periventricular, centrum semiovale, and subcortical white matter were measured. All subjects were scored for clinical motor function. To analyze the changes of FA and ADC values in each ROI area, and to explore the correlation between these changes and clinical scores. Results: There was no significant difference in FA values and ADC values between the left and right ROI of the CSM group(P>0.05). Compared with the healthy control group, the FA values of the various levels of CSM were reduced(P<0.05), and the ADC values of the centrum semioval, the posterior limb of the internal capsule and the pons were increased(P<0.05). The JOA score of the CSM group was lower than that of the control group(P<0.05), and correlated with the FA values of the pons, cerebral peduncle, posterior limb of internal capsule, and the ADC value of the posterior limb of internal capsule. Conclusion: DTI can detect secondary retrograde Wallerian degeneration of CST in patients with CSM, and this retrograde secondary degeneration of CST is associated with the impairment of motor function.
占雅如，何来昌，谭永明，郭建强. 基于DTI的脊髓型颈椎病患者皮质脊髓束逆行性损害的研究[J]. 中国临床医学影像杂志, 2020, 31(4): 238-242.
ZHAN Ya-ru, HE Lai-chang, TAN Yong-ming, GUO Jian-qiang. Study on retrograde degeneration of corticospinal tract in cervical spondylotic myelopathy patients based on DTI. JOURNAL OF CHINA MEDICAL IMAGING, 2020, 31(4): 238-242.
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