T1 mapping成像在宫颈癌组织分化程度评估中的初步应用

doi:DOI:10.12117/jccmi.2020.04.011

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (0 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的：探讨T1 mapping成像在宫颈癌组织分化程度评估中的价值。方法：收集70例经病理证实的宫颈癌患者和30例宫颈正常的其他疾病患者的资料，宫颈癌患者中鳞癌56例，腺癌14例，按照病理分化程度分为中高分化组（49例）和低分化组（21例）。患者均于治疗前行常规MRI、DWI检查，采用Look-Locker序列分别于增强前及增强后5min采集T1 mapping图像，测量肿瘤和正常宫颈的增强前T1弛豫时间（T1pre）、增强后T1弛豫时间（T1post）和ADC值。对比T1pre、T1post和ADC值在肿瘤与正常宫颈、鳞癌与腺癌、中高分化与低分化组间的差别，有统计学意义的参数绘制ROC曲线。结果：肿瘤和正常宫颈的T1pre、T1post、ADC值间差异均有统计学意义（P均＜0.001），鳞癌和腺癌的T1pre、T1post、ADC值间差异均无统计学意义（P均＞0.05），中高分化组的T1post低于低分化组（P＜0.001），中高分化组的ADC值高于低分化组（P=0.002），中高分化组和低分化组的T1pre没有统计学差异（P=0.636），T1post和ADC值鉴别中高分化组和低分化组的ROC曲线下面积分别为0.766、0.736。结论：增强T1 mapping成像可以在一定程度上反映宫颈癌的组织分化程度。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	李淑健
	程敬亮
	张勇
	刘洁
	杨梦
	张斐斐

关键词 ：宫颈肿瘤, 磁共振成像

Abstract：Objective: To explore the value of T1 mapping in assessing grades of uterine cervical cancer. Methods: Seventy patients with pathologically proven cervical cancer and 30 patients with normal cervix underwent conventional MRI and DWI before therapy. Seventy cases of cervical cancer, including 56 cases of squamous cell carcinoma and 14 cases of adenocarcinoma, were divided into well/moderately differentiated tumor group(n=49) and poorly differentiated tumor group(n=21) according to the degree of pathological differentiation. Look-Locker sequences were performed pre and post contrast separately at 5 min after Gd-DTPA administration. T1 relaxation times(T1pre and T1post) and ADC of tumor and normal cervix were measured. The differences in the parameters between cervical cancer and normal cervix, tumor types/grades were compared, and ROC curve was drawn with statistically significant parameters. Results: The difference of T1pre, T1post and ADC was statistically significant between cervical cancer and normal cervix(P＜0.001). There was no significant difference in T1pre, T1post and ADC between squamous cell carcinomas and adenocarcinomas. Compared to the well/moderately differentiated tumor group, poorly differentiated tumor group showed increased T1post and decreased ADC(P=0.000 and P=0.002, respectively). No significant difference was observed for T1pre in differentiated grades of tumor. The areas under ROC curve of T1post and ADC for diagnosis of well/moderately and poorly differentiated tumor were 0.766 and 0.736. Conclusion: Enhanced T1 mapping can reflect the degree of tissue differentiation of cervical cancer to a certain extent.

Key words： Cervix neoplasms Magnetic resonance imaging

收稿日期: 2019-06-27

PACS:	Ｒ737.33
	Ｒ445.2

通讯作者: 程敬亮，郑州大学第一附属医院磁共振科，450052。E-mail：cjr.chjl@vip.163.com

作者简介: 李淑健（1989-），女，河南安阳人，主治医师。E-mail：zzhsj2008@163.com

引用本文:

李淑健，程敬亮，张勇，刘洁，杨梦，张斐斐. T1 mapping成像在宫颈癌组织分化程度评估中的初步应用[J]. 中国临床医学影像杂志, 2020, 31(4): 276-280.
LI Shu-jian, CHENG Jing-liang, ZHANG Yong, LIU Jie, YANG Meng, ZHANG Fei-fei. T1 mapping in evaluation of differentiation of cervical cancer: a primary study. JOURNAL OF CHINA MEDICAL IMAGING, 2020, 31(4): 276-280.

链接本文:

http://www.jccmi.com.cn/CN/DOI:10.12117/jccmi.2020.04.011 或 http://www.jccmi.com.cn/CN/Y2020/V31/I4/276

[1]Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012[J]. CA Cancer J Clin, 2015, 65(2): 87-108. [2]Liu Y, Zhang Y, Cheng R, et al. Radiomics analysis of apparent diffusion coefficient in cervical cancer: A preliminary study on histological grade evaluation[J]. J Magn Reson Imaging, 2019, 49(1): 280-290. [3]李君，吴献华，冯峰，等. 双指数模型DWI对宫颈癌分期及分级诊断的价值[J]. 中国临床医学影像杂志，2018，29（12）：47-51. [4]殷亮，喻思思，龚良庚. 心脏磁共振纵向弛豫时间定量成像技术进展[J]. 中华放射学杂志，2016，50（1）：76-78. [5]Yoon JH, Lee JM, Kang HJ, et al. Quantitative assessment of liver function by using gadoxetic acid-enhanced MRI: hepatocyte uptake ratio[J]. Radiology, 2019, 290(1): 125-133. [6]Adams LC, Ralla B, Jurmeister P, et al. Native T1 mapping as an in vivo biomarker for the identification of higher-grade renal cell carcinoma: correlation with histopathological findings[J]. Invest Radiol, 2019, 54(2): 118-128. [7]Tirkes T, Lin C, Cui E, et al. Quantitative MR evaluation of chronic pancreatitis: extracellular volume fraction and MR relaxometry[J]. AJR, 2018, 210(3): 533-542. [8]Chen CY, Chen J, Xia CC, et al. T1 mapping combined with Gd-EOB-DTPA-enhanced magnetic resonance imaging in predicting the pathologic grading of hepatocellular carcinoma[J]. J Biol Regul Homeost Agents, 2017, 31(4): 1029-1036. [9]Wu Q, Shi D, Dou S, et al. Radiomics analysis of multiparametric MRI evaluates the pathological features of cervical squamous cell carcinoma[J]. J Magn Reson Imaging, 2019, 49(4): 1141-1148. [10]王浩初，樊树峰，高燕，等. 磁共振T1灌注加权成像在宫颈癌诊断中的应用[J]. 中国临床医学影像杂志，2009，20（10）：750-754. [11]张学琴，陆健，张涛，等. 钆塞酸二钠增强T1 mapping成像评估肝功能价值[J]. 中华放射学杂志，2018，52（1）：30-35. [12]陈丽华，任涛，温成龙，等. 体素内不相干运动及T1 mapping成像评估肾移植术后早期肾功能的价值[J]. 中华放射学杂志，2016，50（10）：762-767. [13]Everett RJ, Stirrat CG, Semple SI, et al. Assessment of myocardial fibrosis with T1 mapping MRI[J]. Clin Radiol, 2016, 71(8): 768-778. [14]Wang B, Zhang Y, Zhao B, et al. Postcontrast T1 mapping for differential diagnosis of recurrence and radionecrosis after gamma knife radiosurgery for brain metastasis[J]. AJNR, 2018, 39(6): 1025-1031. [15]Winfield JM, Orton MR, Collins DJ, et al. Separation of type and grade in cervical tumours using non-mono-exponential models of diffusion-weighted MRI[J]. Eur Radiol, 2017, 27(2): 627-636. [16]Arevalo-Perez J, Peck KK, Young RJ, et al. Dynamic contrast-enhanced perfusion MRI and diffusion-weighted imaging in grading of gliomas[J]. J Neuroimaging, 2015, 25(5): 792-798.