Abstract：Objective: To investigate the reference range of the width of fetal cavum septum pellucidum(CSP) at different gestational age and its correlation with gestational age and biparietal diameter, intending to provide a reference basis for clinic. Methods: From January 2018 to May 2019, 1 546 cases of singleton pregnancy without abnormality were collected from the third affiliated hospital of Zhengzhou university for the prenatal ultrasound screening at different gestational age. Logistic regression analysis was used to analyze the change trend of the width of CSP with gestational age and biparietal diameter, Spearman rank correlation coefficient was used to analyze the correlation between the width of CSP and gestational age. Results: In this study, the normal reference range of CSP width was (4.64±1.32) mm, there was a positive correlation(r=0.63, P<0.001) between CSP width and gestational age at 17 to 30 weeks, and there was no significant correlation between CSP width and gestational age at 31 to 37 weeks, the fetal biparietal diameter-to-cavum septum pellucidum ratio(BCR) at 19 to 30 weeks was relatively constant and the reference range was 13.38±3.31. Conclusion: The CSP width is related to the gestational age at 17 to 30 weeks, the BCR is relatively constant at 19 to 30 weeks.
李 洁，王晨静，闫 蕊，栗河舟，郭丽亚. 1 546例胎儿透明隔腔宽度超声测量值分析[J]. 中国临床医学影像杂志, 2020, 31(8): 592-595.
LI Jie, WANG Chen-jing, YAN Rui, LI He-zhou, GUO Li-ya. Analysis of ultrasonic measurement of the width of cavum septum pellucidum in 1 546 fetuses. JOURNAL OF CHINA MEDICAL IMAGING, 2020, 31(8): 592-595.
[1]Winter TC, Kennedy AM, Byrne J, et al. The cavum septi pellucidi: why is it important?[J]. J Ultrasound Med, 2010, 29(3): 427-444.
[2]ISUOG（国际妇产超声协会）. 胎儿中枢神经系统的超声检查操作指南[J/CD]. 中国产前诊断杂志：电子版，2011，3（1）：37-43.
[3]殷林亮，邓学东，梁泓，等. 胎儿透明隔腔缺如的产前超声诊断[J]. 中华医学超声杂志：电子版，2013，10（10）：827-835.
[4]殷林亮，夏飞，邓学东，等. 透明隔腔的产前超声研究进展[J]. 中华医学超声杂志：电子版，2013，10（12）：970-975.
[5]Falco P, Gabrielli S, Visentin A, et al. Transabdominal sonography of the cavum septum pellucidum in normal fetuses in the second and third trimesters of pregnancy[J]. Ultrasound Obstet Gynecol, 2000, 16(6): 549-553.
[6]李彦. 超声检测胎儿透明隔腔宽度及其临床意义[J]. 中国实用医刊，2014，41（9）：84-85.
[7]刘炜，蔡爱露. 透明隔腔的超声诊断及其临床意义[J]. 中国临床医学影像杂志，2008，19（5）：353-355.
[8]曾晴，李胜利. 产前超声评估胎儿胼胝体发育状况的研究进展[J]. 中华医学超声杂志：电子版，2019，16（3）：166-172.
[9]Cooper S, Katorza E, Berkenstadt M, et al. Prenatal abnormal width of the cavum septum pellucidum-MRI features and neurodevelopmental outcome[J]. J Matern Fetal Neonatal Med, 2018, 31(22): 3043-3050.
[10]Pilliod RA, Pettersson DR, Gibson T, et al. Diagnostic accuracy and clinical outcomes associated with prenatal diagnosis of fetal absent cavum septi pellucidi[J]. Prenat Diagn, 2018, 38(6): 395-401.
[11]胡一文，汪玉凤，李玉琴. 透明隔腔异常在胎儿中枢神经系统畸形筛查中的价值[J]. 现代仪器与医疗，2018，24（5）：24-25.
[12]Serhatlioglu S, Kocakoc E, Kiris A, et al. Sonographic measurement of the fetal cerebellum, cisterna magna, and cavum septum pellucidum in normal fetuses in the second and third trimesters of pregnancy[J]. J Clin Ultrasound, 2003, 31(4): 194-200.
[13]田甜，杨太珠，杨帆，等. 产前超声检查与磁共振成像在胎儿透明隔腔异常诊断中的对比分析[J]. 中华妇幼临床医学杂志：电子版，2013，9（3）：376-378.
[14]Shen O, Gelot AB, Moutard ML, et al. Abnormal shape of the cavum septi pellucidi: an indirect sign of partial agenesis of the corpus callosum[J]. Ultrasound Obstet Gynecol, 2015, 46(5): 595-599.
