Abstract：Objective: To evaluate fetal left ventricular function in patients with pregnancy-induced hypertension by using the tissue Doppler Tei index. Methods: One hundred and thirty pregnant women with hypertension were enrolled, including 84 cases of mild preeclampsia and 46 cases of severe preeclampsia. One hundred and thirty pregnant women with matching gestational age were selected as the control group. Tissue Doppler parameters were measured including isovolumetric time(ICT), isovolumetric relaxation time(IRT) and ejection time(ET), and the Tei index was calculated. Both fetal umbilical arteries spectrum and pregnant women’s uterine arteries spectrum were acquired. Results: There was no significant difference in the Tei index between the mild preeclampsia group and the the control group(P>0.05). There was significant difference in Tei index between severe preeclampsia group and control group and mild preeclampsia group(P<0.05). There was significant difference in the incidence of umbilical artery abnormalities beweeen mild preeclampsia group and severe preeclampsia group(χ2=11.33, P<0.01). There was significant difference in the incidence of early diastolic notch of uterine arteries in pregnant women between mild and severe preeclampsia groups(χ2=8.20, P<0.01). Conclusion: By measuring the tissue Doppler Tei index of fetal left ventricular during pregnancy-induced hypertension, the fetal left ventricular function can be estimated, which can provide clinical diagnosis and treatment basis.
李天刚，王艺璇，曹淑娜，王 健，杨 磊，岳志成，马 斌. 组织多普勒Tei指数在妊娠高血压疾病胎儿左心功能评价的应用研究[J]. 中国临床医学影像杂志, 2020, 31(8): 596-599.
LI Tian-gang, WANG Yi-xuan, CAO Shu-na, WANG Jian, YANG Lei, YUE Zhi-cheng, MA Bin. Application of tissue Doppler Tei index in the evaluation of fetal left ventricular function in pregnancy-induced hypertension. JOURNAL OF CHINA MEDICAL IMAGING, 2020, 31(8): 596-599.
[1]乐杰，谢幸，苟文丽. 妇产科学[M]. 7版. 北京：人民卫生出版社，2011：92-99.
[2]李天刚，聂芳，李振东，等. 肺静脉频谱对妊娠高血压疾病胎儿右心舒张功能评价的应用研究[J]. 中国超声医学杂志，2018，34（10）：901-904.
[3]杨钰，曾敏，牛建梅，等. 频谱多普勒超声联合三维能量多普勒超声评估妊娠高血压综合征患者的胎盘功能[J]. 肿瘤影像学，2019，28（2）：112-116.
[4]龙湘党，周启昌，姚穗，等. 速度向量成像技术评估妊娠高血压综合征胎儿心肌节段功能[J]. 中国医学影像学杂志，2014，22（2）：81-86.
[5]李玲玲，张桂萍，迪利努尔，等. 妊娠高血压综合征孕妇胎儿心肌力学变化特点的二维超声斑点追踪显像研究[J]. 新疆医科大学学报，2015，38（12）：1549-1552.
[6]柴囡楠，张昊，李玲旭，等. 宫内缺氧对胎儿、新生儿及成年子代心脏功能的影响及相关研究进展[J]. 心血管病学进展，2016，34（4）：401-404.
[7]Camm EJ, Hansell JA, Kane AD, et al. Partial contributions of developmental hypoxia and undernutrition to prenatal alterations in somatic growth and cardiovascular structure and function[J]. Am J Obstet Gynecol, 2010, 203(5): e24-e34.
[8]Giussani DA, Niu Y, Herrera E, et al. Heart disease link to fetal hypoxia and oxidative stress[J]. Adv Exp Med Biol, 2014, 814: 77-87.
[9]Jonker SS, Giraud MK, Giraud GD, et al. Cardiomyocyte enlargement, proliferation and maturation during chronic fetal anaemia in sheep[J]. Exp Physiol, 2010, 95(1): 131-139.
[10]李天刚，祁平安，王艺璇，等. 组织多普勒Tei指数评价妊娠高血压疾病胎儿右心整体功能的价值[J]. 临床超声医学杂志，2014，16（2）：23-25.
[11]Fadi H, Maqnuson A, Ostlund I, et al. Gestational diabetes mellitus and later cardiovascular disease: a swedish population based casecontrol study[J]． BJOG, 2014, 121(12): 1530-1536.
[12]崔利娜，于江华，张清伟. Tei指数在妊娠期高血压疾病孕妇及胎儿左心室功能评价中的价值[J]. 中国妇产科临床杂志，2016，17（4）：355-356.
[13]张小田，吴青青，姚苓，等. 心脏做功指数自动测量技术在高危妊娠异常胎儿心功能监测方面的应用研究[J]. 中华医学超声杂志：电子版，2016，13（4）：311-315.
[14]Payne BA, Groen H, Ukah UV, et al. Development and internal validation of a multivariable model to predict perinatal death in pregnancy hypertension[J]. Pregnancy Hypertens, 2015, 5(4): 315-321.
[15]Yu N, Cui HY, Chen X, et al. First trimester maternal serum analytes and second trimester uterine artery Doppler in the prediction of preeclampsia and fetal growth restriction[J]. Taiwan J Obstet Gynecol, 2017, 56(3): 358-361.
