Abstract：Objective: To evaluate the correlation between the stability of carotid plaques evaluated by ultrasound and the level of plasma lipoprotein-associated phospholipase A2(Lp-PLA2). Methods: One hundred and eighty-five patients with carotid plaque were divided into stable plaque group(97 cases) and unstable plaque group(88 cases). Two-dimensional ultrasound were used to evaluate the characteristics of all the carotid plaque. Plasma Lp-PLA2 were detected for all the patients. Results: Compared to the stable plaque group, the level of Lp-PLA2 were higher in the unstable plaque group, there was a significant difference between them(P＜0.05). The characteristics of stable plaque: irregular morphology, plaque ulceration, eccentricity index ＞2, liquefaction of the plaque are significantly associated with high plasma Lp-PLA2(P＜0.05). High plasma Lp-PLA2 was an independent risk factor for instability of carotid plaques(P＜0.05). Conclusion: The level of plasma Lp-PLA2 is correlated with the stability of carotid plaque. High plasma Lp-PLA2 is an independent risk factor for instability of carotid plaques(P＜0.05).
李振洲，邵玉凤，陈胜华，关晓韵，吴欣殷，罗舒榆. 颈动脉斑块稳定性超声评估与血浆脂蛋白相关
磷脂酶A2水平的相关性研究[J]. 中国临床医学影像杂志, 2019, 30(3): 166-168.
LI Zhen-zhou, SHAO Yu-feng, CHEN Sheng-hua, GUAN Xiao-yun, WU Xin-yin, LUO Shu-yu. Correlation between stability of carotid plaque evaluated by ultrasound and the level of plasma Lp-PLA2. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(3): 166-168.
[1]Gu X, Hou J, Yang S, et al. Is lipoprotein-associated phospholipase A2 activity correlated with fibrous-cap thickness and plaque volume in patients with acute coronary syndrome[J]. Coron Artery Dis, 2014, 25(1): 10-15.
[2]Reddy RK, Mahendra J, Gurumurthy P, et al. Identification of predictable biomarkers in conjunction to framingham risk score to predict the risk for cardiovascular disease(CVD) in non cardiac subjects[J]. J Clin Diagn Res, 2015, 9(2): BC23-BC27.
[3]Epps KC, Wilensky RL. Lp-PLA2—a novel risk factor for highrisk coronary and carotid artery disease[J]. Intern Med, 2011, 269(10): 94-106.
[4]中国医师协会超声医师分会. 血管和浅表器官超声检查指南[M]. 北京：人民军医出版社，2011：23-28.
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[5]Li GW, Zheng GY, Li JG, et al. Relationship between carotid atherosclerosis and cerebral infarction[J]. Chin Med Sci J, 2010, 25(1): 32-37.
[6]李赵欢，王琳，胡晓波，等. 应用血管内超声弹性成像研究动脉粥样硬化斑块偏心指数与面积应变的关系[J]. 中华超声影像学杂志，2017，26（6）：531-534.
[7]Rallidis LS, Tellis CC, Lekakis J, et al. Lipoprotein-associated phospholipase A(2) boundon high-density lipoprotein is associated with lower risk for cardiac death in stable coronary artery disease patients: a 3-year follow-up[J]. J Am Coll Cardiol, 2012, 60(20): 2053-2060.
[8]Krintus M, Kozinski M, Kubica J, et al. Critical appraisal of inflammatory markers in cardiovascular risk stratification[J]. Crit Rev Clin Lab Sci, 2014, 51(5): 263-279.
[9]Garg PK, McClelland RL, Jenny NS, et al. Lipoprotein-associated phospholipase A2 and risk of incident cardiovascular disease in a multi-ethnic cohort: The multi ethnic study of atherosclerosis[J]. Atherosclerosis, 2015, 241(1): 176-182.
[10]Dallmeier D, Koenig W. Strategies for vascular disease prevention: the role of lipids and related markers including apolipoproteins, low-density lipoproteins(LDL)-particle size, high sensitivity C-reactive protein(hs-CRP), lipoprotein-associated phospholipase A2(Lp-PLA2) and lipoprotein(a)[Lp(a)][J]. Best Pract Res Clin Endocrinol Metab, 2014, 28(4): 281-294.
