Abstract：Objective: To evaluate functional CT in predicting the risks of interventional treatment for primary hepatic carcinoma. Materials and Methods: CT examination and laboratory tests were performed in 97 patients with primary hepatic carcinoma. Before undergoing interventional therapy, remnant hepatic volume measuring and portal perfusion scanning were performed. After interventional therapy, 29 patients showed acute hepatic failure(AHF group), and 68 patients had no hepatic failure(the non-AHF group). Peri-interventional imaging and experimental vairables were analyzed by analysis of variance and χ2 test respectively. The variables of significance(P＜0.05) were analyzed with stepwise logistic regression. Results: Ten variables including remnant hepatic volume per body surface area(RHVS), protal venous perfusion(PVP), hepatic blood flow(HBF), hepatic blood volume(HBV), diameter of catheter used for embolization, portal venous thrombosis, diameter of tumor, serum creatinine, thrombinogen activity, and Child-turcotte-pugh grading(CTP grading). The stepwise logistic regression analysis for the variables demonstrated that decreased RHVS, lowering of PVP, bigger diameter of the catheter and high level of serum creatinine were the independent risk factors of acute hepatic failure complicated to interventional therapy for primary hepatic carcinoma(P＜0.01). Conclusion: Hepatic functional reserve and risks of interventional therapy for primary hepatic carcinoma could be predicted and evaluated by funcional CT.
2014, Vol. 25 
